Company:  KARYOPHARM THERAPEUTICS I ... (KPTI)
Form Type:  SC 13G/A
Filing Date:  2/13/2018 
CIK:  0001503802 
Address:  85 WELLS AVENUE
SECOND FLOOR
 
City, State, Zip:  NEWTON, Massachusetts 02459 
Telephone:  617-658-0600 
Fiscal Year:  12/31 
Last Trade
Last Trade: 
$10.45  
Change: 
0.15 (1.46%)  
Trade Time: 
04:00 PM EST  
Market Cap: 
$634.40M
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Description of Business
We are a clinical-stage pharmaceutical company focused on the discovery, development and subsequent commercialization of novel, first-in-class drugs directed against nuclear transport and related targets for the treatment of cancer and other major diseases. Our scientific expertise is focused on understanding the regulation of intracellular communication between the nucleus and the cytoplasm. We have discovered and are developing wholly-owned, novel, small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). These SINE compounds represent a new class of drug candidates with a novel mechanism of action that have the potential to treat a variety of diseases in areas of unmet medical need. Our SINE compounds were the first oral XPO1 inhibitors in clinical development.
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  FORM SC 13G/A